Rajiv Gandhi Centre for Biotechnology (RGCB), Department of Biotechnology, Government of India

Structural regression modelling of peptide based drug delivery vectors for targeted anti-cancer therapy.

Christian Y, Redkar AS, Kumar N, Jancy SV, Chandrasekharan A, Retnabai Santhoshkumar T , Ramakrishnan V. (2024)

Drug Deliv Transl Res. 2024 Aug 8. doi: 10.1007/s13346-024-01674-y.

Telomerase inhibitors induce mitochondrial oxidation and DNA damage-dependent cell death rescued by Bcl-2/Bcl-xL

Aparna Geetha Jayaprasad, Aneesh Chandrasekharan, S.P. Arun Jyothi, S.M. John Sam, T.R. Santhoshkumar, M. Radhakrishna Pillai (2024)

International Journal of Biological Macromolecules doi.org/10.1016/j.ijbiomac.2024.130151

Genetically encoded caspase sensor and RFP-LC3 for temporal analysis of apoptosis-autophagy.

Chandrasekharan A, Tiwari SK, Munirpasha HA, Sivasailam A, Jayaprasad AG, Harikumar A, Santhoshkumar TR (2023)

Int J Biol Macromol doi: 10.1016/j.ijbiomac.2023.128807

A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity.

Shine Varghese Jancy, Santhik Subhasingh Lupitha, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Shijulal Nelson-Sathi, Roshny Prasad, Sara Jones , Sreekumar Easwaran, Pramod Darvin, Aswathy Sivasailam, Thankayyan Retnabai Santhoshkumar (2023)

Biological Procedures Online doi.org/10.1186/s12575-023-00214-1

Real-time simultaneous imaging of temporal alterations in cytoplasmic and mitochondrial redox in single cells during cell division and cell death

Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Asha Lekshmi, T R Santhoshkumar (2022)

Free Radical Biology and Medicine doi.org/10.1016/j.freeradbiomed.2022.11.031

A rapid bead-based assay for screening of SARS-CoV-2 neutralizing antibodies.

Santhik Subhasingh Lupitha, Pramod Darvin, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Soumya Jaya Divakaran, Sreekumar Easwaran, Shijulal Nelson-Sathi, Perunthottathu K Umasankar, Sara Jones, Iype Joseph, Madhavan Radhakrishna Pillai, Thankayyan Retnabai Santhoshkumar (2022)

Antibody Therapeutics doi.org/10.1093/abt/tbac007

Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria.

Rishith Ravindran, Anoop Kumar G Velikkakath, Nikhil Dev Narendradev, Aneesh Chandrasekharan, T R Santhoshkumar, Srinivasa M Srinivasula (2022)

Autophagy doi.org/10.1080/15548627.2022.2052460

ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine.

Seervi M., Rani A., Sharma A.K., Santhosh Kumar T.R.(2018)

Biomed Pharmacother 106, 200-209.

Biosynthesized composites of Au-Ag nanoparticles using Trapa peel extract induced ROS-mediated p53 independent apoptosis in cancer cells.

Ahmad N., Sharma A.K., Sharma S., Khan I., Sharma D.K., Shamsi A., Santhosh Kumar T.R., Seervi M., (2018)

Drug Chem Toxicol. doi: 10.1080/01480545.2018.1463241.

Streptomyces sp metabolite(s) promotes Bax mediated intrinsic apoptosis and autophagy involving inhibition of mTOR pathway in cervical cancer cell lines.

Dan V.M., Muralikrishnan B., Sanawar R., J S.V., Burkul B.B., Srinivas K.P., Lekshmi A., Pradeep N.S., Dastager S.G., Santhakumari B., Santhoshkumar T.R, M Kumar R.A., Pillai M.R., 2018.

Sci. Rep. 8, 2810.

Strategies for imaging mitophagy in high-resolution and high-throughput.

Indira, D., Varadarajan, S.N., Subhasingh Lupitha, S., Lekshmi, A., Mathew, K.A., Chandrasekharan, A., Rajappan Pillai, P., Pulikkal Kadamberi, I., Ramachandran, I., Sekar, H., KochucherukkanGopalakrishnan, A., Tr S.( 2018)

European journal of cell biology 97(1): 1-14.

A Real-Time Image-Based Approach to Distinguish and Discriminate Apoptosis from Necrosis.

Lekshmi, A., Varadarajan, S.N., Lupitha, S.S., Nair, M., Chandrasekharan, A., Santhoshkumar T.R.(2018).

Current protocols in toxicology 21;75:2.27.1-2.27.16

Santhosh Kumar T . R, PhD

Scientist G

Selected Publications