Selected Publications

Direct DNA binding by BRCA1 on β-hCG promoter and its clinical implications

Neethu Krishnan , Neetha R L , Arathy V. Warrier , Induprabha Yadev , Jaimie Anandan , Sankar Sundaram , Arathi Rajan ,Prianka Kumari , Shreya Sara Ittycheria , Manasa V.G ,Serbin Mohammed , Preethamol S , Rakesh Sathish Nair , Priya Srinivas (2024)

Heliyon Volume 10 Issue 17e37064 September 15 2024

Xenoestrogen and Its Interaction with Human Genes and Cellular Proteins: An In-Silico Study

Arathy V Warrier , Manasa Vg , Neetha R L , Neethu Krishnan , Prianka Kumari , Shreya Sara Ittycheria , Priya Srinivas (2024)

Asian Pacific Journal of Cancer Prevention (APJCP) 25(6):2077-2087 Doi: 10.31557/APJCP.2024.25.6.2077. IF : 2.514

βhCG mediates immune suppression through upregulation of CD11b⁺Gr1⁺ Myeloid Derived Suppressor Cells, CD206⁺M2 macrophages, and CD4⁺FOXP3⁺ regulatory T-cells in BRCA1 deficient breast cancers.

Geetu Rose Varghese, Dipyaman Patra, Vishnu Sunil Jaikumar, Arathi Rajan, Neetha R Latha, Priya Srinivas (2023)

Immunology 1-16; DOI: 10.1111/imm.13673 IF : 7.397

Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers

Arathi Rajan, Geetu R Varghese, Induprabha Yadev, Jaimie Anandan, Neetha R Latha, Dipyaman Patra, Neethu Krishnan, Krithiga Kuppusamy, Arathy V Warrier, Satej Bhushan, Revathy Nadhan, Ram Mohan Ram Kumar, Priya Srinivas (2022)

American Journal of Cancer Research 12(1):17-47

BRCA1 promoter hypermethylation in human placenta: A hidden link with β-hCG expression

Revathy Nadhan, Jayashree V V, Satheesh K S, Sreelatha K H, C Nirmala, Santha S, P V Aysha, Sreelekha Y, R S Krishnapriya, B V Amritha K, Sreevidya P S, Arathi R, Neetha R L, Geetu R V, Ratheeshkumar T, Sarada A, Dev S U Jithin, T V A Kumar, Priya Srinivas^* (2020)

Carcinogenesis 41(5):611-624. doi:10.1093/carcin/bgz117 IF. 5.334

β-hCG-induced mutant BRCA1 ignites drug resistance in susceptible breast tissue.

Satheesh Kumar Sengodan, Sreelatha K Hemalatha, Revathy Nadhan, Thara Somanathan, Arun Peter Mathew, Arkadiusz Chil, Janusz Kopczynski, Rakesh Sathish Nair, Jerald Mahesh Kumar, Priya Srinivas^* (2019)

Carcinogenesis 40(11):1415-1426. doi:10.1093/carcin/bgz070 IF. 5.334

BRCA1 Defective Breast Cancer Cells Induce in vitro Transformation of Cancer Associated Fibroblasts (CAFs) to Metastasis Associated Fibroblasts (MAF)

Sreelatha KH, Satheesh KS, Revathy N, Jithin Dev, Reshma R S, Veena S, Ratheeshkumar T, Arathi R, Neetha R L, Geetu R V, Arun Peter M, Thara S, and Priya Srinivas^*. (2018)

Scientific Reports 8(1):13903. IF. 4.01

Proteomic profiling of β-hCG induced spheres in BRCA1 defective triple negative breast cancer cells.

Satheesh Kumar Sengodan, Arathi Rajan, Sreelatha Krishnakumar Hemalatha, Revathy Nadhan, Abdul Jaleel and Priya Srinivas^*. (2018)

Journal of Proteome Research 17(1):276-289. doi:10.1021/acs.jproteome.7b00562 IF. 4,268

BRCA1 regulation on β-hCG: A mechanism for tumorigenicity in BRCA1 defective breast cancer.

Satheesh K S, Revathy N, Rakesh S N, Sreelatha K H, Veena S, Reshma R S, Arathi R, Neetha R L, Geetu R V, Ratheeshkumar T, Jerald M K, Arkadiusz C, Thapasimuthu V A, Priya Srinivas*(2017)

Oncogenesis, Sep 4;6(9):e376. doi: 10.1038/oncsis.2017.75 IF. 5.021

See complete publication list

Chapters in Book / Text

1. Reshma R S, Revathy Nadhan and Priya Srinivas. Plumbagin and Prostate Cancer Therapy. In the book "Complementary and Alternative Medicines in Prostate Cancer: A Comprehensive Approach", ISBN 9781498729871 - CAT# K26099, by CRC Press, December 6, 2016.
2. Satheesh Kumar S, Sreelatha K H,, Revathy Nadhan, and Priya Srinivas. Role of BRCA1 in Breast Cancer Metastasis. Charpter 1, In the book "Gynecologic Cancers - Basic Sciences, Clinical and Therapeutic Perspectives", ISBN 978-953-51-4278-2, InTech, Europe, March 2nd, 2016.
3. Revathy Nadhan, Priya Srinivas, M Radhakrishna Pillai. RTKs in Pathobiology of Head and Neck Cancers. Advances in Cancer Research (Elsevier) - Receptor Tyrosine Kinases in Cancer Progression and Therapeutics. Under Communication

Abstracts / Presentations / Invited Lectures

Conference Presentations

Priya Srinivas, Shankar Sashidhar, Glycoprotein levels in cateractous Lens, Abstract, Proceedings Kerala Science Congress, 1995.
Priya Srinivas, Iqhal Ahmed, Elizabeth Abraham, K.S.Nair, P.P.Nair, V.G.Chellam, N.R.Vijayalekshmy, M.K.Nair & Prabha Balaram. NM23H1and C-ERB B2 in Breast Cancers. National Conference on Molecular Diagnostics,Trivandrum, Kerala, June 27-29,1998.
Priya Srinivas, Elizabeth Abraham, K.S.Nair, Iqbal Ahamed, Chellam.P.p.Nair, N.R.Vijayalakshmy, M.K.Nair and Prabha Balaram. IS NM23H1 Gene Related to Apoptosis in Breast Cancer. InternationalSymposium on Apoptosis, October 30-31, 1998.
Priya Srinivas, Elizabeth Abraham, Iqbal Ahmed, Chellam V G, N R Vijayalakshmi, M K Nair and Prabha Balaram. P53 and PCNA expression as indicators of Metastasis in nfiltrating Ductal Carcinomas. Abstract, p183-85, Proceedings of 11th Kerala Science Congress, Kasaragod, Feb 27- Mar 1, 1999.
Priya Srinivas, Prabha Balaram, Paul Murugan, Elizabeth Abraham, Iqbal Ahmed, N.R. Vijayalakshmi and M.K. Nair. C-erbB2 oncogene expression and its correlation with tumour suppressor genes, proliferation and other epidemiologic parameters in node negative and node positive breast cancers. XV Asia Pacific Cancer Conference, Madras, Dec. 12th - 15th, 1999.
Priya Srinivas, Elizabeth Abraham, Sukumaran N, Iqbal Ahamed, Balaraman Nair M, Prabha Balaram. Prognostic value of antimetastatic protein nm23H1 and tumor suppressor protein p53 in Breast cancers. Proceedings of 13th Kerala Science Congress, Jan, 2001.
Maya Madhavan, Priya Srinivas, Iqbal Ahmed, Elizabeth Abraham, N.R. Vijayalakshmi and Prabha Balaram. Cadherins as markers of nodal metastasis in breast cancers.19th annual convention of Indian Association for Cancer Research, Thrissur, Jan 21-23, 2000.
Priya Srinivas, P Murugan, E Abraham, N.R. Vijayalakshmi, P Balaram. BRCA1gene alterations in patients with breast cancer in Kerala: A preliminary report. Proceedings of 14th Kerala Science Congress, Jan 29-31, 2002.
Maya Madhavan, Prabha Balaram and Priya Srinivas. E-cadherin probably linked to cell proliferation in Breast Cancer. Proceedings of 14th Kerala Science Congress, Jan 29-31, 2002.
Priya Srinivas, Maya Madhavan, N. R. Vijayalakshmi, Prabha Balaram. Cyclin D1 and c-erbB-2 expression in breast cancer. IABMS, Pondicherry, 2002.
Priya Srinivas, Prabha Balaram, Sangeetha Mohan, Maya Madhavan, Iqbal Ahmed, Elizabeth Abraham and N.R. Vijayalekshmi. Alterations of p53 and BRCA1genes in breast carcinoma. Indian Association for Cancer Research 22nd Annual Convention and International Symposium on Recent Advances in Cancer Causes and Control; Jan 10-12, 2003.
Maya Madhavan, Abraham E, Ahmed I, Vijayalakshmi N.R, Srinivas P and Balaram P. Beta Catenin mutatiopns in relation to histology, stage and metastatic potential of breast cancer - A preliminary study. Indian Association for Cancer Research 22nd Annual Convention and International Symposium on Recent Advances in Cancer Causes and Control; Jan 10-12, 2003.
Srinivas G, Ruby john Anto, Priya Srinivas, Karunagaran D. Emodin induces apoptosis of human cervical cancer cells through induction of poly (ADP ribose) polymerase cleavage and activation of caspases. Abstract p 129, 22nd Annual meeting of Indian Association of Cancer Research, Thiruvananthapuram, January 10-12, 2003.
Priya Srinivas and Gopal Srinivas. Plumbagin inhibits nuclear translocation of ERa in BRCA1 blocked ER overexpressing BG-1 ovarian cancer cells. Indian Science Congress, Kolkatta, Jan, 2004.
Rojini.G, Thasni.K.A, Ratheeshkumar.T, Srinivas G and Priya Srinivas. Anticancer activity of genistein on BRCA1 blocked estrogen receptor (ER) positive BG1 ovarian cancer cells. International Symposium on translational research ,apoptosis and cancer, 18th to 21st December 2005.
Thansi KA, Srinivas G and Priya Srinivas. Plumbagin induces RAB 18 in the absence of BRCA1 in ovarian cancer cells. International Symposium on translational research, apoptosis and cancer, 18th to 21st December 2005.
Priya Srinivas, Thansi KA and Rakesh.S A study of effects of Cisplatin and Doxorubicin in comparison to Plumbagin in BRCA1 blocked human ovarian cancer cells. SL.27 International Symposium on translational research, apoptosis and cancer, 18th to 21st December 2005.
Sreekala Nair, Priya Srinivas, Reghuram Nair, and M Radhakrishna Pillai. Invitro characterization of plumbagin as a radiosensitizer for Cervical cancer cells. Pp 95, International Symposium on translational research ,apoptosis and cancer, 18th to 21st December 2005 (Second best poster award)
Suboj Babykutty, Jose Padikkala, Priya Srinivas, Gopal Srinivas. Growth inhibitory and apoptosis inducing effect of methanolic extract of centella asiatica (L) in MCF-7 cells. Pp 60, International Symposium on translational research, apoptosis and cancer, 18th to 21st December 2005.
Thasni K.A, Rakesh S, Rojini G, Ratheeshkumar T, Srinivas G, Asoke Banerji, Priya Srinivas. Plumbagin a magic bullet in BRCA1 mutated cancer therapy Abstract published in proceedings of national seminar conducted by societies for biotechnologists India December 2006.
Thasni K A, Shivakumar K.C, Priya Srinivas. Mechanism of action of plumbagin in BRCA1 blocked ovarian cancer cells: an analysis by suppression subtractive hybridization (SSH) and micro array published in the proceedings of 19th kerala science congress held at Kannur, Kerala January 2007.
Thasni K A, Rojini G, Srinivas G, Asoke Banerji, Priya Srinivas .Molecular mechanism of action of plumbagin in BRCA1 blocked ovarian cancer cell line by suppression subtractive hybridization and micro array Proceedings of the 5th International Symposium on Targeted Anticancer Therapies 2007, held at Amsterdam, The Netherlands on March 8-10, 2007.
Priya Srinivas, Thasni K A, Rakesh S Nair, Rojini G, Ratheeshkumar T, AsokeBanerji, Srinivas G, Targeted anticancer therapy for BRCA1 blocked estrogen receptor positive ovarian cancers. Proceedings of the 5th International Symposium on Targeted Anticancer Therapies 2007, held at Amsterdam, The Netherlands on March 8-10, 2007
Thasni K A, Rakesh S Nair, Rojini G, Ratheesh kumar T, Srinivas Gopal, Asoke Banerjj, Priya Srinivas Naphthaquinones - Promising anticancer agents against breast and ovarian cancer treatment. 30th breast cancer symposium, San Antonio, Texas. December 2007.
Rakesh S Nair, Sivakumar K.C., Eswaranpotti Manoj, Ratheesh kumar. T, M.R. Prathapachandra Kurup, Srinivas G and Priya Srinivas. Induced fit DNA recognition in a cisplatin binding groove by carbohydrazone: structural fluctuations investigated through molecular dynamics simulations. Proceedings of International Symposium on Computational Biology, Bioinformatics and Synthetic biology, held at Centre for Bioinformatics, University of Kerala, Thiruvananthapuram, India, January 2008.
Sangeetha S Nampoothiri, Ratheeshkumar T, Rakesh S Nair, Thasni K A, Srinivas G and Priya Srinivas. Combination Therapy Using Taxol, Cisplatin, Doxorubicin with Plumbagin on Bg1 Ovarian Adenocarcinoma Cell Line. 2008 Inflammation, Microenvironment and Cancer (D2) 3/30/2008 to 4/4/2008; Snowbird, UT; USA.
Priya Srinivas, Rakesh S Nair, Prathapachandra Kurup M.R and Mini Kuriakose. Molecular trail for the action of a metal based drug in HPV positive cervical cancer cells. The Seventh Annual AACR International Conference on Frontiers in Cancer Prevention, Washington, DC, U.S.A, 16th to 21st December,2008.
Rakesh Sathish Nair, Thasni K A, Jerald Mahesh Kumar, Asoke Banerji, Srinivas G and Priya Srinivas. Transition of a molecule from Indian indigenous medicine to the arena of molecular cancer research.17th Annual Short Course on Experimental Models of Human Cancer at Jackson laboratory, Bar Harbour, Maine, USA, 22nd to 31st August 2008
In vitro Anticancer activity of alo emodin involves G2/M arrest and inhibition of metastasis in colon cancer cells. Priya Prasanna Sathiadevan, Suboj Babykutty, Vinod Vijayakurup, Priya Srinivas,Gopal Srinivas. International PSE symposioum on Natural products in cancer therapy. Italy, 2008
Srinivas Gopala, M Radhakrishna Pillai, Priya Srinivas. Molecular mechnism of plumbagin action: an update on its antitumor function. International PSE Symposium on Natural Products in Cancer Therapy, 23-26 September 2008, Naples Italy.
Nitric oxide-cGMP-MMP2/9 circuit in colon cancer migration and invasiveness: An in vitro study. Suboj Babykutty, Priya Prasanna Sathiadevan, Vinod Vijayakurup, Padmakrishnan. C. J, Priya Srinivas, Gopal Srinivas. ECCO 15 -ESMO 34 Multidisciplinary Congress, Berlin, 2009.
Rakesh S, J Mahesh Kumar, Jedy Jose, Anil Kumar T V, Chuxia Deng, Priya Srinivas. Quinone as drug targets against homologous recombination deficient tumors, International cancer research Symposium-20-22nd, December 2010.
Priya Srinivas, Veena Somasundaram, Rakesh S, Thasni KA, Premakumari P, Srinivas G. Multifaceted approach with a single drug for BRCA1 defective cancers. Current Medicinal Chemistry, Special Issue, Abstracts- 3rd International Conference on Drug Discovery and Therapy, Dubai, Feb, 2011, p 107.
Veena Somasundaram, Priya Srinivas. A Study of Breast cancer stem cells isolated from BRCA1 mutated cell lines in comparison to those isolated from cell lines with wild type BRCA1' paper presented and won consolation prize at 'The 2nd International Conference on Stem Cells and Cancer (ICSCC-2011)- Proliferation, Differentiation and Apoptosis', Pune, 15th -18th October, 2011.
Priya Srinivas, Rakesh S Nair, Sutapa Singha, Debabrata Mukhopadhyay, Differential sensitivity patterns of a naphthaquinone in cancer: possible mechanisms to BRCA1 and BRCA2 genes. 21st Asia Pacific Cancer Conference, Kuala Lumpur, Malaysia. November 10-12, 2011.
Suboj Babykutty, Priya Prasanna Sathiadevan, Priya Srinivas, S Gopala. Insidious role of nitric oxide in migration / invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. 21st Asia Pacific Cancer Conference, Kuala Lumpur, Malaysia. November 10-12, 2011.
Veena Somasundaram, Sreelatha K H, Reshma R S, Rakesh S and Priya Srinivas. 'Defects in BRCA1-Novel clues to targeting Breast Cancer Stem Cells.' Paper Presented at the 32nd Annual Convention of the Indian Asociation for Cancer Research, University of Delhi (North Campus) from February 13-16, 2013.
Sreelatha KH, Reshma RS, Veena S, Rakesh SN, Thara Somanathan, Jem Prabhakar, and Priya Srinivas. Mammary Cancer Associated Fibroblast (CAF) mediated breast tumor progression, an in vitro study. Poster Presented at the 32nd Annual Convention of the Indian Asociation for Cancer Research, University of Delhi (North Campus) from February 13-16, 2013.
Reshma RS, Sreelatha KH, Veena Somasundaram, Rakesh SN, Priya Srinivas. Castrate Resistant Prostate Cancer and Naphthaquinones. Poster Presented at the 32nd Annual Convention of the Indian Asociation for Cancer Research, University of Delhi (North Campus) from February 13-16, 2013.
S Veena, KH Sreelatha, RS Reshma, SN Rakesh, S Priya. 'Carboplatin and ALDH1+ Breast Cancer Stem Cells: Unseen Facts. Poster Presented at the 11th International Congress on Targeted Anticancer Therapies, Paris, France, March 4-6, 2013. Annals of Oncology 24 (Supplement 1): i30-i32, 2013.
S Priya, RS Reshma, SN Rakesh, KH Sreelatha, S Veena. 'Novel Phytochemical to target BRCA2 Related Prostate Cancer. Poster Presented at the 11th International Congress on Targeted Anticancer Therapies, Paris, France, March 4-6, 2013. Annals of Oncology 24 (Supplement 1): i23-i26, 2013
K. H. Sreelatha, R. S. Reshma, S. Veena, S. N. Rakesh, S. Thara, P. Jem, S. Priya. Influence of Cancer Associated Fibroblast (CAF) on human breast cancer cells in an in vitro co-culture model. Poster Presented at the 11th International Congress on Targeted Anticancer Therapies, Paris, France, March 4-6, 2013. Annals of Oncology 24 (Supplement 1): i30-i32, 2013
Veena Somasundaram, Reshma RS, Sreelatha KH, Revathy, Satheesh Kumar S, Priya Srinivas. 'Inducers of NO and ROS: Implications in Homologous Recombination Defective Breast Cancer Cells'. Poster presented at the Legacy of Nitric Oxide Discovery: Impact on Disease Biology, Rajiv Gandhi Centre for Biotechnology, Kerala, India, November 5-6, 2013
Revathy, Sreelekha Y, Sreevidya P S, Sreelatha K H, Veena Somasundaram and Priya Srinivas. Etiopathogenesis of Gestational Trophoblastic Diseases in Indian population. Poster presented at 33^rd Annual Convention of Indian Association of Cancer Research, Kollam, Kerala, 13^th to 15^th February 2014.
S.Satheesh Kumar, Revathy , Sreelatha K.H , Veena Somasundaram and Priya Srinivas. β-hCG: a key molecule in Triple Negative BRCA1-/- Breast Cancer?. Poster presented on 33^nd Annual conference on Indian Association of Cancer Research held at Kollam, Kerala, February 13-15, 2014.
Reshma R S, Priya Srinivas. Identification of genes with altered expression in response to vitamin K3 analogue in prostate cancer cells. Poster presented on 33^nd Annual conference on Indian Association of Cancer Research held at Kollam, Kerala, February 13-15, 2014.
Reshma R S, Sreelatha K H, Veena S, Priya Srinivas. "In vitro evidences for the therapeutic potential of a naphthaquinone derivative in prostate cancer stem like cells (PCSLCs)” International Symposium on 'New Perspectives in Modern Biotechnology' organized by SAB (Society for Applied Biotechnology). The Accord Hotel, Puducherry, Tamil Nadu, India, March 23 -25, 2015.
Revathy Nadhan, Krishnapriya R S, Nirmala C, Jayashree V Vaman, Santha Sadasivan, Aysha P V, Sreevidya P S, Satheesh Kumar S, Sreelatha K H, Balaraman Nair M , Anilkumar T V and Priya Srinivas. Gestational Trophoblastic Diseases – BRCA1 – Breast Cancer : An Enthralling Trio. Poster presented at Fourth AACR International Conference on Frontiers in Basic Cancer Research, Pennsylvania Convention Centre, Philadelphia, Pennsylvania, USA, 23^rd to 26^th October 2015.
Satheesh Kumar S, Sreelatha K H, Revathy Nadhan and Priya Srinivas. β-hCG: The key culprit in BRCA1 mutated triple negative breast cancer?. Poster presented at Fourth AACR International Conference on Frontiers in Basic Cancer Research, Pennsylvania Convention Centre, Philadelphia, Pennsylvania, USA, 23^rd to 26^th October 2015.
Sreelatha KH, Arun Peter Mathew, Thara Somanthan, Jithin Dev, Veena Somasundaram,Reshma RS, Satheesh Kumar S, Revathy, Priya Srinivas. A study on the decisive role of activated fibroblast, Cancer Associated Fibroblast (CAFs) cells on triple negative breast cancer cells. Paper presented on Global Cancer Summit held at J.N.Tata Auditorium, Indian Institute of Science, Bengaluru from November 18-20^th, 2015.
Revathy nadhan, Nirmala C, Jayashree V vaman, Krishnapriya RS, Santha Sadasivan, Aysha P V, Sreevidya P S, Satheesh Kumar S, Sreelatha Kh, Balaraman Nair M, Anilkumar T V, Priya srinivas. An insight into the role of ERM proteins in the etiopathology of trophoblastic tumors. Paper presented on Global Cancer Summit held at J.N.Tata Auditorium, Indian Institute of Science, Bengaluru from November 18-20^th, 2015.
Satheesh Kumar S, Sreelatha KH, Revathy N, Priya Srinivas Influence of pregnancy hormone, hCG on Triple Negative Breast cancer cells. Paper presented on Global Cancer Summit held at J.N.Tata Auditorium, Indian Institute of Science, Bengaluru from November 18-20^th, 2015.
Somasundaram Veena, Sreelatha KH, Reshma RS, Rakesh SN, Priya SrinivasDNA intercalator or ROS inducer: Novel Clues for Targeting ALDH1+ Breast Cancer Stem Cells“6^th International Symposium on Translational Cancer Research- Prevention and Treatment of Cancer: Hypes and Hopes” held during 04-07- February, 2016 at Hyatt Regency, Ahmedabad, Gujarat, India.
Sreelatha KH, Satheesh Kumar S, Revathy, Jithin Dev, Reshma RS, Veena Somasundaram, Arun Peter Thomas, Thara Somanathan,Priya Srinivas “Revamping Cancer Associated Fibroblast to Metastasis Associated fibroblast: Impact of BRCA1 mutation in breast cancer metastasis”. Poster presented at the Disease Biology Symposium held at Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram on 9th November, 2016.
Sreelatha K H, Satheesh K Sengodan, Revathy Nadhan, Jithin Dev, Reshma R S, Arun Peter Thomas, Thara Somanathan, Priya Srinivas. Cancer Associated Fibroblasts adaptation to the metastatic environment: Influence of BRCA1 deficient cancer cells. Invited Lecture at the 3^6th Annual Conference of Indian Association for Cancer Research, 9^th to 11^th February 2017, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India.
Satheesh Kumar Sengodan, Sreelatha K H, Revathy Nadhan, Rakesh Sathish Nair, Jerald Mahesh Kumar, T V Anilkumar and Priya Srinivas. β-hCG and BRCA1 in breast cancer. Oral presentation at the 36^th Annual Conference of Indian Association for Cancer Research, 9^th to 11^th February 2017, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India.
Revathy Nadhan, Satheesh Kumar Sengodan, Sreelatha Krishnakumar Hemalatha, Jayashree V Vaman, Nirmala C, Priya Srinivas. BRCA1 looming into the future of vesicular mole patients: an analysis at the molecular and cohort level. Oral presentation at the 3^6th Annual Conference of Indian Association for Cancer Research, ^9th to 1^1th February 2017, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India.
Arathi Rajan, Neetha R L, Revathy Nadhan, Sreelatha K H, Satheesh Kumar S, Priya Srinivas The imprints of Estrogen receptor alpha (ER- α) in DNA damage repair. Oral presentation at the 36^th Annual Conference of Indian Association for Cancer Research, 9^th to 11^th February 2017, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India.
Priya Srinivas, Satheesh Kumar Sengodan, Revathy Nadhan, Arathi Rajan, Neetha R L, Geetu Rose Varghese, Ratheeshkumar Thankappan. Tumorigenic role of β-hCG in BRCA1 defective Triple Negative Breast Cancer, World Congress on Cancer, WCC-2018, Mahatma Gandhi Medical College and Hospital, Jaipur, February 3-5, 2018, Won "First Best poster Presentation Award".
Priya Srinivas;Pregnancy hormone hCG in Igniting tumorigenesis in BRCA1 Defective Breast tissues 7th International Conference on Translational Cancer Research from February 8 -11, 2018, in Chennai (Madras), India, (Invited talk).
Priya Srinivas International Conference on Cell Death in Cancer and Toxicology β-hcg: A key player for BRCA1 defective tumorigenesis, CSIR, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, U.P., India , February 20-22, 2018, (Invited talk).
Arathi Rajan, Neetha R L, Revathy Nadhan, Satheesh Kumar S, Geetu Rose, Ratheesh Kumar T andPriya Srinivas*, “ER-α: The Inextricable Dictator in BRCA1 mediated DNA Damage Repair“. Poster presented on 37th Annual Meet IACR, Kolkata. Shri Rambhau Kulkarni Award for Best Poster, 2018.
Satheesh Kumar S, Revathy Nadhan, Neetha R L, Geetu Rose, Arathi Rajan, Ratheesh Kumar T and Priya Srinivas*, “The pregnancy hormone, β-hCG promotes tumorigenesis and drug resistance in BRCA1 defective Triple Negative Breast Cancer“. Poster presented on 37th Annual Meet IACR, Kolkata. Shri Rajanikant Shivprasad Baxi Award for Best Poster, 2018
Geetu Rose, Arathi Rajan, Neetha R L, Revathy Nadhan, Satheesh Kumar S, Ratheesh Kumar T and Priya Srinivas* “Immune modulation and βhCG Expression in BRCA1 mutated breast Cancers.. Poster presented on 37th Annual Meet IACR, Kolkata, 2018
Ratheesh Kumar T, Satheesh Kumar S, Arathi Rajan, Neetha R L, Revathy Nadhan, Geetu Rose and Priya Srinivas*. “Generation of BRCA1 knockout MCF-7 cells by CRISPR/CAS9 technology” Poster presented on 37th Annual Meet IACR, Kolkata. 2018
Revathy Nadhan, Satheesh Kumar Sengodan, Arathi Rajan, Neetha R L, Geetu Rose Varghese, Ratheeshkumar T, Jayashree V Vaman, Nirmala C andPriya Srinivas^*. “BRCA1: A Cardinal Facet in the Etio-Pathology of Hydatidiform Moles”, Oral presentation on 37th Annual Meet IACR, Kolkata. 2018.
Priya Srinivas, Satheesh Kumar Sengodan, Revathy Nadhan, Arathi Rajan, Neetha R L, Geetu Rose Varghese, Ratheeshkumar Thankappan. Tumorigenic role of β-hCG in BRCA1 defective Triple Negative Breast Cancer, World Congress on Cancer, WCC-2018, Mahatma Gandhi Medical College and Hospital, Jaipur, February 3-5, 2018.
Priya Srinivas, Pregnancy hormone hCG in Igniting tumorigenesis in BRCA1 Defective Breast tissues 7th International Conference on Translational Cancer Research from February 8 -11, 2018, in Chennai (Madras), India, (Invited talk).
Priya Srinivas, International Conference on Cell Death in Cancer and Toxicology β-hcg: A key player for BRCA1 defective tumorigenesis, CSIR, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, U.P., India , February 20-22, 2018, (Invited talk).
Priya Srinivas, Hereditary aspects of Breast Cancer, Department of Zoology, Kerala University
Priya Srinivas, “Targeting BRCA1 mutated cancers" “International work shop on Basic Tools and Techniques in molecular Biology", Department of Botany, University College, Thiruvananthapuram, 17-19^th Dec, 2018. (Invited talk).
Geetu Rose Varghese, Arathi Rajan, Sathish Kumar, Revathy Nadhan, Neetha R L,Priya Srinivas*.“Expression of pro-inflammatory and anti-inflammatory cytokines in BRCA1 mutated breast cancers". Poster presented at 37^th Annual conference on Indian Association of Cancer Research held at Bose Institute, Kolkatta, February 23-25, 2018.
Arathi Rajan, Neetha R L,Priya Srinivas.”ER-α: The Paramount facet Predisposing BRCA1 defective tumors”. Poster presentation at the 2018Annual meet Of American Association For Cancer Research, 14^th to 18^th April 2018, McCormick Place, Chicago,IL, USA.
Priya Srinivas. “A comparison of the mechanism of tumorigenesis in brca1 defective cancers and gestational trophoblastic diseases”. 38th Annual Convention of Association for Cancer Research (IACR 2019), March 2019, Department of Biochemistry, PGI, Chandigarh, (Invited talk).
Neetha R L, Vishnu Sunil Jaikumar, Arathy V Warrier,Priya Srinivas‘‘BRCA1 Mutant Cancer cell Metastasis and its impact on Tumor Stromal Fibroblasts”. Oral presentation at the 4^th International Conference on Nutraceuticals and Chronic Diseases INCD2019, 23^rdto 25^thSeptember 2019 , Indian Institute of Technology Guwahati, Assam, India.
Neetha R L, Geetu Rose Varghese, Vishnu Sunil Jaikumar, Arathi Rajan, Revathy Nadhan Arathy Warrier,Priya Srinivas. “BRCA1 Mutation in Breast Cancer Cells and Generation of Metastasis Associated Fibroblasts”. Poster presentation at the AACR Tumor Immunology and Immunotherapy Special Conference, 17^th - 20^th November, 2019, Boston Marriott Copley Place, Boston, MA,USA.
Geetu Rose Varghese, Vishnu Sunil Jaikumar , Arathi Rajan, Neetha R L, Dipyaman Patra,Priya Srinivas “βhCG regulates immune cell population in BRCA1 mutated breast cancers”. Poster presentation at the AACR Tumor Immunology and Immunotherapy Special Conference, 17^th - 20^th November, 2019, Boston Marriott Copley Place, Boston, MA,USA.
Revathy Nadhan, Neetha R L, Neethu Krishnan, Dipyaman Patra,Priya Srinivas. When Origami and Scientific Research Converge: “Foldscope” as a cost efficient aid in visualization of microscopic contaminants in mammalian cell culture. Poster presented at 38th Annual Convention of Indian Association for Cancer Research held at PGIMER, Chandigarh, March 1-3, 2019.
Neetha R L, Arathi Rajan, Geetu Rose Varghese, Revathy Nadhan, Krithiga Kuppusamy ,Sreelatha Krishnakumar Hemalatha , Thara Somanathan, Arun Peter Mathew,Priya Srinivas “Tumor Stromal Fibroblasts and BRCA1 Mutant Cancer Cell Metastasis”. Poster presentation at the 38th Annual Convention of Indian Association for Cancer Research, 1st to 3rd March 2019, Hotel Mount view, Chandigarh, India.
Arathi Rajan, Neetha R L, Revathy Nadhan, Sreelatha K H, Satheesh Kumar S,Priya Srinivas“Does ER- α mantle BRCA1 mediated DNA Damage Repair?”. Oral presentation at the International Seminar on Recent Biochemical Approaches in Therapeutics, (RBAT-IV), Dept. of Biochemistry, University of Kerala.
Geetu Rose Varghese, Arathi Rajan, Neetha R L, Revathy Nathan,Priya Srinivas. βhCG regulates myeloid derived suppressor cell population in susceptible breast cancers”. Oral presentation at Biochemistry Talks, Targeting Metabolism in Non-Communicable Diseases Organized by Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 02 August 2019.
Geetu Rose Varghese, Vishnu Sunil Jaikumar, Arathi Rajan, Dipyaman Patra,Priya Srinivas*.“Impact of β-hCG in regulating the immune cell population in BRCA1 mutated breast cancers”. 8th International Translational Cancer Research Conference: “Role of Inflammation and Immune System for Cancer Prevention and Treatment” held on February 13-16, 2020 at Banaras Hindu University, Varanasi.
Dipyaman Patra, Geetu Rose Varghese, Arathi Rajan,Priya Srinivas*. BRCA1 Hypermethylation in Sporadic Breast Tumorigenesis: Unravelling the role of NBR2 and β-hCG. Poster presented on 14th February, 2020 at 8th Translational Cancer Research Conference, 2020.
Neetha RL, Geetu Rose Varghese, Vishnu Sunil Jaikumar, ArathiRajan, Revathy Nadhan,Arathy V. Warrier, Neethu Krishnan,Priya Srinivas. “BRCA1: The Unrivaled Determinant in Transfiguring CancerAssociated Fibroblasts to Metastasis Associated Fibroblasts”. Poster presented on 39th Annual conference on Indian Association of Cancer Research held on RGCB, Thiruvanathapuram, February 5-7, 2020.
Geetu Rose Varghese, Vishnu Sunil Jaikumar, Arathi Rajan, Neetha R L, Dipyaman Patra,Priya Srinivas* “CD206+/CD163+ M2 Macrophage polarization and induction of CD4+CD25+ T-regulatory cells by hCG in BRCA1 defective cancers”. at the 39th Annual Conference of Indian Association for Cancer Research conference held on February 3-7, 2020 at Udaya Samudra, Kovalam, Thiruvananthapuram.
Revathy Nadhan, Satheesh Kumar Sengodan, Arathi Rajan, Neetha R L, Neethu Krishnan, Jayashree V Vaman, Nirmala C, Priya Srinivas. Plumbagin rescinds the BRCA1 promoter hypermethylation in Gestational Trophoblastic Diseases. Poster presented at 39th Annual Conference of Indian Association for Cancer Research held at Thiruvananthapuram, from February 5-7, 2020.
Krithiga K., Arya Aravind, Geetu Rose Varghese, Arathi Rajan, Neetha R.L., Neethu Krishnan, Dipyaman Patra, Revathy Nadhan AndPriya Srinivas. Developing A Standard FNAC Protocol for Canine Mammary Carcinoma Grading. Poster Presented On 39th Annual Conference on Indian Association of Cancer Research Held At RGCB, Thiruvananthapuram, February 5-7, 2020.
Dipyaman Patra, Geetu Rose Varghese, Arathi Rajan,Priya Srinivas*. BRCA1 Hypermethylation in Sporadic Breast Tumorigenesis: Unravelling the role of NBR2 and β-hCG. Poster presented on 3rd February, 2020 at 39th Annual Conference of Indian Association for Cancer Research (IACR), Held At RGCB, Thiruvananthapuram, February 5-7, 2020

Abstracts Published

Neetha Rajan Latha, Geetu Rose Varghese, Vishnu Sunil Jaikumar, Arathi Rajan, Revathy Nadhan, Arathy Warrier and Priya Srinivas Abstract B91: BRCA1 mutation in breast cancer cells and generation of metastasis associated fibroblasts. Cancer Immunol Res March 1 2020 (8) (3 Supplement) B91; DOI: 10.1158/2326-6074.TUMIMM19-B91. IF 8.619.
Geetu Rose Varghese, Vishnu Sunil Jaikumar, Arathi Rajan, Neetha Rajan Latha, Dipyaman Patra and Priya Srinivas. (2020). βhCG regulates immune cell population in BRCA1 mutated breast cancers. Cancer Immunol Res. Abstract A57: (8) (3 Supplement) A57; DOI: 10.1158/2326-6074.TUMIMM19-A57. IF 8.619.
Arathi Rajan, Neetha Rajan Latha, Priya Srinivas. ER-α: The paramount facet predisposing BRCA1 defective tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3384. DOI: 10.1158/1538-7445.AM2018-3384, IF 9.130
Veena Somasundaram, Sreelatha KH, Reshma RS, Rakesh SN, Priya Srinivas ‘Carboplatin and ALDH1+ Breast Cancer Stem Cells: Unseen Facts. Annals of Oncology, Supplement 1, March, 2013, p i30. IF 6.578.
Sreelatha KH, Reshma RS, Veena Somasundaram, Rakesh SN, Thara Somanthan, Jem Prabhakar, Priya Srinivas. Influence of Cancer Associated Fibroblast (CAF) on human breast cancer cells in an invitro co-culture model. Annals of Oncology 24 Supplement 1, March, 2013, p i30. IF 6.578.
Priya Srinivas, Reshma RS, Rakesh S, Sreelatha KH, Veena Somasundaram. Novel phytochemical to target BRCA2 related prostate cancer. Annals of Oncology 24 Supplement 1, March, 2013, p i25. IF 6.578.
Priya Srinivas, Veena Somasundaram, Rakesh S, Thasni KA, Premakumari P, Srinivas G. Multifaceted approach with a single drug for BRCA1 defective cancers. Current Medicinal Chemistry, Special Issue, (Abstract), p 107, 2011,. IF: 4.63
P Sathiadevan, S Babykkutty, C J jayakrishnan, S Gopala, Priya Srinivas. Aloe emodin, a natural anthraquinone targeting multiple facets (migration, invasion, angiogenesis) of tumour metastasis. September 2009. EJC Supplements 7(2):95-95.
Priya Srinivas, Rakesh S Nair, Prathapachandra Kurup M.R and Mini Kuriakose. Molecular trail for the action of a metal based drug in HPV positive cervical cancer cells. (Abstract), Cancer Prevention Research: Volume 1, Issue 7, Supplement. doi: 10.1158/1940-6207.PREV-08-A71, November 2008. IF: 4.978
Thasni K A, Rakesh S Nair, Rojini G, Ratheesh kumar T, Srinivas Gopal, Asoke Banerjj, Priya Srinivas Naphthaquinones - Promising anticancer agents against breast and ovarian cancer treatment. (Abstract) - Breast Cancer Research and Treatment, Vol 106, Supplement 1, December 2007. IF : 4.2
Thasni K A, Rojini G, Srinivas G, Asoke Banerji,Priya Srinivas. Molecular mechanism of action of plumbagin in BRCA1 blocked ovarian cancer cell line by suppression subtractive hybridization and micro array. (Abstract) Annals of Oncology, Volume 18, Supplement 4, May 2007. IF : 5.17
Priya Srinivas, Thasni K A, Rakesh S Nair, Rojini G, Ratheeshkumar T, Asoke Banerji, Srinivas G. Targeted anticancer therapy for BRCA1 blocked estrogen receptor positive ovarian cancers. (Abstract) Annals of Oncology, Volume 18, Supplement 4, May 2007. IF : 5.17

Priya Srinivas, PhD

Scientist G & Dean (Academic Affairs)

Selected Publications

Direct DNA binding by BRCA1 on β-hCG promoter and its clinical implications

Xenoestrogen and Its Interaction with Human Genes and Cellular Proteins: An In-Silico Study

βhCG mediates immune suppression through upregulation of CD11b⁺Gr1⁺ Myeloid Derived Suppressor Cells, CD206⁺M2 macrophages, and CD4⁺FOXP3⁺ regulatory T-cells in BRCA1 deficient breast cancers.

Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers

BRCA1 promoter hypermethylation in human placenta: A hidden link with β-hCG expression

β-hCG-induced mutant BRCA1 ignites drug resistance in susceptible breast tissue.

BRCA1 Defective Breast Cancer Cells Induce in vitro Transformation of Cancer Associated Fibroblasts (CAFs) to Metastasis Associated Fibroblasts (MAF)

Proteomic profiling of β-hCG induced spheres in BRCA1 defective triple negative breast cancer cells.

BRCA1 regulation on β-hCG: A mechanism for tumorigenicity in BRCA1 defective breast cancer.

Chapters in Book / Text

Abstracts / Presentations / Invited Lectures

Conference Presentations

Abstracts Published

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Priya Srinivas, PhD

Scientist G & Dean (Academic Affairs)

Selected Publications

Direct DNA binding by BRCA1 on β-hCG promoter and its clinical implications

Xenoestrogen and Its Interaction with Human Genes and Cellular Proteins: An In-Silico Study

βhCG mediates immune suppression through upregulation of CD11b+Gr1+ Myeloid Derived Suppressor Cells, CD206+M2 macrophages, and CD4+FOXP3+ regulatory T-cells in BRCA1 deficient breast cancers.

Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers

BRCA1 promoter hypermethylation in human placenta: A hidden link with β-hCG expression

β-hCG-induced mutant BRCA1 ignites drug resistance in susceptible breast tissue.

BRCA1 Defective Breast Cancer Cells Induce in vitro Transformation of Cancer Associated Fibroblasts (CAFs) to Metastasis Associated Fibroblasts (MAF)

Proteomic profiling of β-hCG induced spheres in BRCA1 defective triple negative breast cancer cells.

BRCA1 regulation on β-hCG: A mechanism for tumorigenicity in BRCA1 defective breast cancer.

Chapters in Book / Text

Abstracts / Presentations / Invited Lectures

Conference Presentations

Abstracts Published

βhCG mediates immune suppression through upregulation of CD11b⁺Gr1⁺ Myeloid Derived Suppressor Cells, CD206⁺M2 macrophages, and CD4⁺FOXP3⁺ regulatory T-cells in BRCA1 deficient breast cancers.