The Main Campus, located at Jagathy, in the heart of Kerala’s capital city, is where RGCB’s conducts most of its discovery research programs. The campus concentrates on Disease Biology Research and does innovative studies in cellular, and molecular mechanisms of human, animal, and plant diseases. The range of disease areas under investigation includes cancer, atherosclerosis and heart disease, tuberculosis, viral infections, cholera, neurological disorders, reproductive problems, and fungal diseases in plants.

The campus employs modern technologies such as high throughput sequencing, DNA bar-coding, synthetic biology, nano-biotechnology, and chemical biology to develop delivery systems, understand the fundamentals of cellular function during disease, and characterize the molecular taxonomy of disease manifestations